Symptomatic muscle involvement in neurosarcoidosis: a clinicopathological study of 5 cases

Arquivos de Neuro-Psiquiatria

Rosana Herminia Scola¹  Lineu Cesar Werneck¹  Daniel Monte Serrat Prevedello¹  Priscila Greboge¹  Fábio Massaiti Iwamoto¹ 

[1] ,Federal University of Paraná Hospital de Clínicas Department of Internal MedicineCuritiba PR ,Brazil

关键词: sarcoidosis;    myositis;    granuloma;    central nervous system diseases;    sarcoidose;    miosite;    granuloma;    doenças do sistema nervoso central;   

DOI  :  10.1590/S0004-282X2001000300007

来源: SciELO

【 摘 要 】

We report on the clinical course and histopathologic muscle alterations of five patients diagnosed with neurosarcoidosis, who underwent biopsy due to their muscle manifestations. The five patients were females and only one was less than 40 years of age. Proximal muscle weakness was presented by all and only two patients complained of myalgia. Only normal values of serum muscle enzymes were detected. Electromyography revealed diverse findings such as normal, myopathic and neuropathic patterns. Granuloma was not present in one muscle biopsy. Two patients thoroughly recovered by taking only prednisone and one patient required a methotrexate addition for 3 months before becoming asymptomatic. The other two patients received azathioprine, one due to steroid side effects but without a satisfactory evolution, and the other to strengthen the prednisone régime, with excellent results.

【 授权许可】

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