Multiple sclerosis in Brazil: analysis of cerebrospinal fluid by standard methods

Arquivos de Neuro-Psiquiatria

Marzia Puccioni-sohler¹  Fabiola Passer¹  Cristiane Oliveira¹  Carlos OtÁvio BrandÃo¹  Regina Papaiz-alvarenga¹ 

[1] ,Projeto Atlântico Sul Laboratório Especializado de LCR Rio de Janeiro,Brazil

关键词: multiple sclerosis;    cerebrospinal fluid;    oligoclonal bands;    isoelectric focusing;    esclerose múltipla;    líquido cefalorraquidiano;    bandas oligoclonais;    focalização isoelétrica;   

DOI  :  10.1590/S0004-282X1999000600005

来源: SciELO

【 摘 要 】

The demonstration of intrathecal IgG synthesis has been used as an important laboratory parameter to support the diagnosis of multiple sclerosis(MS). The Committee for European Concerted Action for Multiple Sclerosis has recommended a protocol for the assessment of intrathecal IgG synthesis. We applied this methodology to determine the cerebrospinal (CSF) profile of 128 Brazilian patients with MS. We detected hypercytosis lower than 35 cells/mm3 in 97%, protein lower than 80mg/dl in 99%, normal blood-CSF barrier function in 76%, increased IgG local production around 53% and oligoclonal IgG bands by isoelectric focusing in 85% of the definite MS patients. The diagnostic accuracy of the quantitative analysis was lower than the qualitative. The detection of oligoclonal bands was especially important in the cases of normal quantitative assays of IgG. In addition, we found a lower frequency of inflammatory reaction in CSF in our MS cases, in comparison to some European studies.

【 授权许可】

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