The effect of baclofen on spontaneous and evoked behavioural expression of experimental neuropathic chronic pain

Arquivos de Neuro-Psiquiatria

Terezinha De Jesus T. Santos²  Carlos M. De Castro-costa²  SÍlvio D. A. Giffoni²  Franklin J. C. Santos²  Rodrigo S. N. Ramos¹  Marcus A. C. Gifoni¹ 

[1] ,Federal University of Ceará (UFC) Department of Physiology and Pharmacology Laboratory of Experimental Neurology,Brazil

关键词: baclofen;    experimental neuropathic pain;    Bennet's model;    scratching behaviour;    thermal stimulus;    analgesia;    baclofeno;    dor neuropática experimental;    modelo de Bennet;    comportamento de coçar-se (scratching);    estímulos térmicos;    analgesia;   

DOI  :  10.1590/S0004-282X1999000500005

来源: SciELO

【 摘 要 】

Baclofen (beta-p-chlorophenyl-GABA) has been used in humans to treat spasticity, as well as trigeminal neuralgia. Since GABA (gamma-aminobutyric acid) has been implicated in inhibitory and analgesic effects in the nervous system, it was of interest to study the effect of baclofen in experimental neuropathic pain. With this purpose, experiments were carried out in 17 neuropathic rats with constrictive sciatic injury, as described by Bennet and Xie (1988), taking as pain parameters scratching behaviour and the latency to the thermal nociceptive stimulus. The results showed that baclofen induces, in a dose-dependent manner, significant decrease (p < 0.05) of scratching behaviour and significant increase (p < 0.05) of the latency to the nociceptive thermal stimulus. The absence of antagonism of naloxone suggested a non-participation of an opioid-mediated mechanism in this analgesic effect of baclofen on experimental neuropathic pain.

【 授权许可】

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