HTLV-I associated myelopathy in patients from Brazil and Iran: neurological manifestations and cerebrospinal fluid findings

Arquivos de Neuro-Psiquiatria

Marzia Puccioni-sohler¹  Bernid Kitze¹  Klaus Felgenhauer¹ 

[1] ,Georg-August-UniversitáGöttingen,Germany

关键词: HTLV-I;    HAM;    cerebrospinal fluid;    multiple sclerosis;    HTLV-I;    mielopatia;    HAM;    líquido cefalorraquidiano;    esclerose múltipla;   

DOI  :  10.1590/S0004-282X1995000200005

来源: SciELO

【 摘 要 】

We analysed sera and cerebrospinal fluid (CSF) of 20 cases of human T-cell lymphotropic virus type (HTLV-I) associated myelopathy/tropical spastic paraparesis (HAM/TSP) from Brazil and Iran and as controls, 16 Brazilian HTLVI seronegative individuals afflicted with other neurological diseases. It was observed in the HAM/TSP patients that: 1) all had an inflammatory reaction within the central nervous system (CNS); 2) 95% (19/20) showed oligoclonal bands reflecting intrathecal IgG synthesis; 3) 85% (17/20) presented a local synthesis of HTLVI antibodies; 4) 35% (7/20) had a measurable immunoglobulin (Ig) synthesis within the CNS. The CSF parameters of the HAM/TSP were compared with the clinical data (age at onset, duration of disease and disability level). Our data prove that CSF analysis is important for the diagnosis of HAM/TSP. There is no association between the severity of the disease and CSF findings.

【 授权许可】

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