LUNG AND LIVER CHANGES DUE TO THE INDUCTION OF CIRRHOSIS IN TWO EXPERIMENTAL MODELS

Arquivos de Gastroenterologia

Renata Salatti Ferrari¹  Mauricio Tieppo¹  Darlan Pase Da Rosa¹  Luiz Alberto Forgiarini Jr¹  Alexandre Simoes Dias¹  Norma Possa Marroni¹ 

关键词: Liver diseases;    Lung diseases;    Liver cirrhosis experimental;    Carbon tetrachloride;    diagnostic use;    Common bile duct;    physiopathology;    Diseases models;    animal;    Hepatopatias;    Pneumopatias;    Cirrose hepatica experimental;    Tetracloreto de Carbono;    uso diagnostico;    Ducto coledoco;    fisiopatologia;    Modelos animais de doencas;   

DOI  :  10.1590/S0004-28032013000200037

来源: SciELO

【 摘 要 】

Context To evaluate lung and liver changes in two experimental models using intraperitoneal carbon tetrachloride (CCl4) and bile duct ligation (BDL). Methods Twenty-four male Wistar rats were divided into a control group (CO) and an experimental group (EX). We evaluated the liver transaminases (AST, ALT, AP), arterial blood gases (PaO2, PCO2 and SpO2) and lipid peroxidation by TBARS (substances that react to thiobarbituric acid) and chemiluminescence. We also evaluated the antioxidant enzyme superoxide dismutase (SOD) and histology of lung tissue and liver. Results There were significant differences in AST, ALT, ALP and PaO2 between CO group and EX group (P<0.05). The levels of TBARS, chemiluminescence and activity of enzyme superoxide dismutase were increased to different degrees in the CCl4 groups: CO and in the BDL -EX (P<0.05, respectively). In the lung histology, an increase in the wall thickness of the pulmonary artery and a diameter reduction in the CCl4 animal model were observed: comparing CO group with EX group, we observed a reduction in thickness and an increase in the diameter of the artery wall lung. Conclusion Both experimental models have caused liver damage and alterations in the artery wall that are associated with major changes in pulmonary gas exchange.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License