Helicobacter pylori antibiotic resistance in Brazil: clarithromycin is still a good option

Arquivos de Gastroenterologia

Jaime Natan Eisig¹  Fernando Marcuz Silva¹  Ricardo Correa Barbuti¹  Tomás Navarro-rodriguez¹  Joaquim Prado P Moraes-filho¹  José Pedrazzoli Jr¹ 

[1] ,Universidade de São Paulo Faculdade de Medicina Hospital das ClínicasSão Paulo SP ,Brasil

关键词: Helicobacter pylori;    Drug resistance;    microbial;    Clarithromycin;    Amoxicillin;    Helicobacter pylori;    Resistência microbiana a medicamentos;    Claritromicina;    Amoxilina;   

DOI  :  10.1590/S0004-28032011000400008

来源: SciELO

【 摘 要 】

CONTEXT: The antibiotic susceptibility is the cornerstone for the eradication therapies of Helicobacter pylori. OBJECTIVES: To evaluate the prevalence of primary resistance of H. pylori was evaluated in an urban Brazilian population. METHODS:H. pylori isolates were obtained from patients submitted to an upper gastrointestinal endoscopy for the evaluation of dyspeptic symptoms. Biopsies from antrum, corpus and fundus were taken to determine the antibiotic susceptibility of H. pylori isolates. The minimal inhibitory concentration of furazolidone and bismuth were routinely determined by agar dilution method and the minimal inhibitory for amoxicillin, clarithromycin, tetracycline, levofloxacin, and metronidazole were routinely determined with the E-test. RESULTS: Fifty-four patients were included. In vitro antimicrobial susceptibility of H. pylori strains were obtained from 39 patients. Resistance to metronidazole was detected in 20 patients (51%), to clarithromycin in 3 patients (8%), to levofloxacin in 9 patients (23%) and to bismuth in 2 patients (5%). There was no observed resistance to amoxicillin, tetracycline or furazolidone. CONCLUSION: Due to the low amoxicillin and clarithromycin resistance observed in this study, therapies using these antimicrobials remain appropriated first-line H. pylori therapy.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License