Gluco-lipidic indices in treated hypothyroidism associated with nonalcoholic fatty liver disease

Arquivos de Gastroenterologia

Daniel Ferraz De Campos Mazo¹  Vicência Mara Rodrigues De Lima¹  Jose Tadeu Stefano¹  Fabiola Rabelo¹  Joel Faintuch¹  Claudia Pinto De Oliveira¹ 

[1] ,University of São Paulo School of Medicine Department of GastroenterologySão Paulo SP ,Brazil

关键词: Glycolipids;    Fatty liver;    Hypothyroidism;    Glicolipídios;    Fígado gorduroso;    Hipotireoidismo;   

DOI  :  10.1590/S0004-28032011000300006

来源: SciELO

【 摘 要 】

CONTEXT: Thyroid hormones may interfere with regulation of lipid and carbohydrate metabolism as well as with severity of nonalcoholic fatty liver disease (NAFLD), however results are still debated. OBJECTIVES: Retrospective evaluation of clinical and metabolic correlations between hypothyroidism and NAFLD was the target. METHODS: Clinical, biochemical and histological investigation of 103 NAFLD patients exhibiting drug-treated hypothyroidism was conducted. RESULTS: Steatosis was present in 32.0% of the population and nonalcoholic steatohepatitis in 68.0%. Females were the majority in both groups, with age of 50.0 ± 1.5 and 56.0 ± 1.1 years, respectively. Hypothyroidism was not rare (15.5%), and multivariate analysis confirmed positive correlation with this disease for insulin (r = 0.213, P = 0.03), glucose homeostasis index "HOMA" (r = 0.221, P = 0.02), aspartate aminotransferase (r = 0.234, P = 0.01) and triglycerides above 150 mg/dL (r = 0.233, P = 0.01). No association between hypothyroidism and steatohepatitis could be established. CONCLUSION: A link could be identified between hypothyroidism and markers of glucose and lipid homeostasis, but not with severity of NAFLD. The lack of correlation with liver biopsy requires further studies.

【 授权许可】

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