Antibodies anti-Saccharomyces cerevisiae (ASCA) do not differentiate Crohn's disease from celiac disease

Arquivos de Gastroenterologia

Lorete Maria Da Silva Kotze²  Renato Mitsunori Nisihara¹  Shirley Ramos Da Rosa Utiyama¹  Paulo Gustavo Kotze²  Petra Mirella Theiss²  Márcia Olandoski¹ 

[1] ,Pontifícia Universidade Católica do Paraná Hospital Cajuru

关键词: Saccharomyces cerevisiae;    Crohn disease;    Celiac disease;    Diet;    gluten-free;    Saccharomyces cerevisiae;    Doença de Crohn;    Doença celíaca;    Dieta livre de glúten;   

DOI  :  10.1590/S0004-28032010000300006

来源: SciELO

【 摘 要 】

CONTEXT: Anti-Saccharomyces cerevisiae antibodies (ASCA), considered serologic markers for Crohn's disease, were described in patients with celiac disease, disappearing after a gluten-free diet. OBJECTIVES: Evaluation of ASCA positivity in patients with Crohn's disease and celiac disease in relation to healthy individuals. METHODS: A total of 145 individuals were studied: 36 with Crohn's disease and 52 with celiac disease, that fulfilled the diagnostic criteria for both affections, and 57 healthy individuals for control. The celiac patients were divided as follow: group CeD I at diagnosis (n = 34), group CeD II with gluten-free diet compliance (n = 13) and group CeD III with transgressions to the diet (n = 5). ASCA IgA and IgG were determined by ELISA. RESULTS: With statistical significance, ASCA IgA were positive in Crohn's disease, celiac disease at diagnosis and celiac disease with diet transgressions; ASCA IgG in Crohn's disease and in all groups with celiac disease. CONCLUSIONS: The detection of ASCA in patients with celiac disease allows to suggest that ASCA is not a specific marker for Crohn's disease, but was associated with the inflammation of the small intestine. The increased levels of positive ASCA may be due to genetic factors and increased intestinal permeability.

【 授权许可】

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