Morphine does no promote esophageal carcinogenesis in rats exposed to diethylnitrosamine

Arquivos de Gastroenterologia

Carlos Frota Dillenburg²  Cleber Dario Pinto Kruel²  Carlos Thadeu Cerski¹  Maria Isabel Edelweiss¹  Tiago Luís Dedavid E Silva¹  André Silvio Schier¹ 

[1] ,Federal University of Rio Grande do Sul Departments of Surgery Porto Alegre RS ,Brazil

关键词: Esophageal neoplasms;    Carcinoma;    squamous cell;    Morphine;    Diethylnitrosamine;    Rats;    Neoplasias esofágicas;    Carcinoma de células escamosas;    Morfina;    Dietilnitrosamina;    Ratos;   

DOI  :  10.1590/S0004-28032008000100016

来源: SciELO

【 摘 要 】

BACKGROUND: The high incidence of esophageal cancer in the north of Iran has been associated to the consumption of opium and exposure to nitrosamines. Diethylnitrosamine has an established potential of producing experimental cancer in the esophagus and liver. AIM: To evaluate by histopathology the effect of oral administration of morphine and diethylnitrosamine during 23 weeks on the hepatic and esophageal carcinogenesis on 176 rats. METHODS: We divided the rats into the following groups: Morph: morphine; Den: diethylnitrosamine; Den+morph: Den and morphine in the same solution; Den/morph: Den and morphine in different solutions and days. RESULTS: Morphine did not promote neoplasias. The highest neoplastic incidents were found: a) in the esophagus, Den in relation to Den/morph and Den+morph (71.1%, 55.8%, and 50.0%); b) in the liver, Den and Den/morph in relation to Den+morph (73.8%, 81.4%, and 40.9%); c) higher incident of hepatic neoplasia than esophageal in Den/morph (81.4% and 55.8%). Different doses of diethylnitrosamine were ingested among the groups Den, Den/morph, and Den+morph, respectively 2.9, 2.8, and 2.3 mg/kg/day. CONCLUSIONS: These results show that the morphine did not promote esophageal carcinogenesis and may have stimulated the hepatic metabolism of the first pass of the carcinogen.

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