Prevalence of hepatopulmonary syndrome in patients with decompensated chronic liver disease and its impact on short-term survival

Arquivos de Gastroenterologia

Palmireno Pinheiro Ferreira¹  Edmundo José Nasri Camara¹  Rogério Luis Porto De Paula¹  Cláudio Celestino Zollinger¹  Andréa Ribeiro Cavalcanti¹  Paulo Lisboa Bittencourt¹ 

[1] ,Portuguese Hospital of Salvador Unit of Gastroenterology and Hepatology

关键词: Hepatopulmonary syndrome;    Liver diseases;    Chronic disease;    Inpatients;    Síndrome hepatopulmonar;    Hepatopatias;    Doença crônica;    Pacientes internados;   

DOI  :  10.1590/S0004-28032008000100007

来源: SciELO

【 摘 要 】

BACKGROUND: Hepatopulmonary syndrome is reported to occur in 4% to 32% of the patients with chronic liver disease and is associated with poor liver function and shortened patient survival before and after liver transplantation. AIMS: To assess the frequency of hepatopulmonary syndrome in Brazilian patients with decompensated chronic liver disease and to investigate its impact on patient survival. METHODS: One hundred and thirty patients (101 males, mean age 61 ± 12 years) with decompensated chronic liver disease were evaluated for the presence of hepatopulmonary syndrome. The diagnosis of hepatopulmonary syndrome was considered in the presence of alveolar arterial oxygen gradient of more than 15 mm Hg and of pulmonary vascular dilatation assessed by contrast enhanced echocardiography. RESULTS: Hepatopulmonary syndrome was observed in 21 (16%) patients. The presence of hepatopulmonary syndrome was significantly associated with severity of liver disease assessed by the MELD (Model for End-Stage Liver Disease) score, but not with in hospital mortality after admission due to decompensated chronic liver disease. CONCLUSIONS: Hepatopulmonary syndrome occurs in 16% of patients with chronic liver disease and is associated with disease severity according to the MELD score. Short term mortality following decompensation of chronic liver disease was not associated with hepatopulmonary syndrome.

【 授权许可】

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