Conjunctival melanoma: survival analysis in twenty-two Mexican patients

Arquivos Brasileiros de Oftalmologia

Rosa Angélica Salcedo-hernández¹  Kuauhyama Luna-ortiz¹  Leonardo Saúl Lino-silva¹  Ángel Herrera-gómez¹  Verónica Villavicencio-valencia¹  Miriam Tejeda-rojas¹  José F. Carrillo¹ 

关键词: Conjunctival neoplasms/surgery;    Melanoma;    Disease-free survival;    Survival analysis;    Neoplasias da conjuntiva/cirurgia;    melanoma;    Sobrevida livre de doença;    Análise de sobrevivência;   

DOI  :  10.5935/0004-2749.20140040

来源: SciELO

【 摘 要 】

Purpose: To describe the cases of conjunctival melanoma (CM) and report the disease-free interval (DFI) and overall survival (OS). Methods: The charts of 22 patients who were admitted to two hospitals between 1985 and 2006 were reviewed for pertinent data, including demographics, site of involvement in the conjunctiva and sub-sites, surgical treatment, and adjuvant treatment. Results: There were 10 (45.45%) males and 12 (54.55%) females. Mean age was 52.3 years. In this group, 15 patients (68.1%) involved the bulbar conjunctiva, and 7 (31.9%) involved the palpebral conjunctiva. Of the 22 patients, 72.72% had a history of conjunctival melanosis. The average tumor size was 20.4 mm. Eight (36.36%) patients underwent orbital exenteration, 2 (9.06%) had enucleation, 5 (22.72%) had wide excision of the lesion followed by radiotherapy, 2 (9.06%) had orbital exenteration with neck dissection, and the remaining 5 patients (22.72%) were considered adequately treated only with wide excision. Eight (36.36%) patients received adjuvant treatment. Disease-free survival at 5 years was 51% and the overall survival at 5 and 10 years was 50% and 37%, respectively. Conclusion: Conjunctival melanoma is a rare entity. Tumor behavior is aggressive, and the optimal treatment is surgery with adjuvant therapy.

【 授权许可】

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