Primary localized amyloidosis presenting as diffuse amorphous calcified mass in both orbits: case report

Arquivos Brasileiros de Oftalmologia

Allan Christian Pieroni Gonçalves¹  Rodrigo Bernal Da Costa Moritz¹  Mário Luiz Ribeiro Monteiro¹ 

[1] ,Universidade de São Paulo Department of Ophthalmology São Paulo SP ,Brazil

关键词: Amyloidosis;    Orbit diseases;    Exophthalmos;    Magnetic resonance imaging;    Ophthalmoplegia;    Humans;    Female;    Middle aged;    Case report;    Amiloidose;    Doenças orbitárias;    Exoftalmo;    Imagem por ressonância magnética;    Oftalmoplegia;    Humanos;    Feminino;    Meia-idade;    Relato de caso;   

DOI  :  10.1590/S0004-27492011000500015

来源: SciELO

【 摘 要 】

Primary localized amyloidosis is rare in the orbit. We report the case of a 63-year-old woman that presented with bilateral proptosis and ophthalmoplegia. A computed tomography scan revealed an infiltrative amorphous and markedly calcified mass in both orbits while a magnetic resonance scan showed a heterogeneous hypointense signal on T2-weighted images. A biopsy was performed through an anterior orbitotomy. Microscopy revealed extracellular amorphous and eosinophilic hyaline material which stained pink with Congo red and displayed green birefringence on polarized microscopy, leading to a diagnosis of amyloidosis. The results of the systemic workup were completely normal. A two-year follow-up period without any treatment disclosed no worsening of the condition. While calcification of nonvascular orbital lesions has often been regarded as suggestive of malignant disease, our case is a reminder that it can also be a characteristic presenting sign of orbital amyloidosis.

【 授权许可】

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