Indocyanine green-mediated photothrombosis for choroidal neovascularization in angioid streaks

Arquivos Brasileiros de Oftalmologia

Fernando Korn Malerbi²  Sheau Jiun Huang¹  Fabio Bom Aggio¹  Edenilson Carvalho Jr.¹  Pedro Paulo Bonomo¹  Michel Eid Farah¹ 

[1] ,Universidade Federal de São Paulo Departamento de Oftalmologia São Paulo SP ,Brasil

关键词: Angioid streaks;    Choroidal neovascularization;    Indocyanine green;    Photochemotherapy;    Photosensitizing agents;    Lasers;    Tomography;    optical coherence;    Estrias angióides;    Neovascularização coroidal;    Verde de indocianina;    Fotoquimioterapia;    Agentes fotossensibilizantes;    Lasers;    Tomografia de coerência óptica;   

DOI  :  10.1590/S0004-27492008000300002

来源: SciELO

【 摘 要 】

PURPOSE: To investigate the effect of indocyanine green-mediated photothrombosis on choroidal neovascularization secondary to angioid streaks. METHODS: Six eyes of 5 patients with an average age of 70 years were diagnosed to have subfoveal choroidal neovascularization secondary to angioid streaks. Therapy was indicated if choroidal neovascularization was considered to be active, according to evidence of fluorescein leakage on angiograms, as well as presence of intra- or subretinal fluid on optical coherence tomography. Patients received photothrombosis at baseline with retreatment as necessary at 3, 6 and 9 months follow-up. Fluorescein leakage was assessed at 3, 6 and 9 months, along with foveal thickness measured by optical coherence tomography. Indocyanine green angiography was performed initially and whenever retreatment was considered. Retreatment was performed whenever there was evidence of increased leakage on fluorescein angiograms at follow-up visits. RESULTS: The mean follow-up was 13.3 months. All eyes had at least 12 months follow-up. Two eyes underwent retreatment. Three eyes had visual acuity improvement and three eyes had stabilization. All patients showed less fluorescein leakage on final angiograms and reduced foveal thickness upon optical coherence tomography measurement. CONCLUSION: Photothrombosis is a feasible procedure for choroidal neovascularization secondary to angioid streaks. Lesion analysis showed anatomical improvement in most cases in this series. Further studies are warranted to evaluate long-term results of this treatment.

【 授权许可】

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