Fluoroquinolone susceptibilities to methicillin-resistant and susceptible coagulase-negative Staphylococcus isolated from eye infection

Arquivos Brasileiros de Oftalmologia

Adália Dias Dourado Oliveira²  Ana Luisa Höfling-lima¹  Rubens Belfort Jr.¹  Maria De Fátima Gayoso¹  Waldemar Francisco¹ 

[1] ,Universidade Federal de São PauloSão Paulo SP ,Brasil

关键词: Drug resistance;    Eye infections;    bacterial;    Staphylococcus;    Coagulase;    Fluoroquinolones;    Methicillin-resistance;    Resistência microbiana a drogas;    Infecções oculares bacterianas;    Staphylococcus;    Coagulase;    Fluoroquinolonas;    Resistência a meticilina;   

DOI  :  10.1590/S0004-27492007000200018

来源: SciELO

【 摘 要 】

PURPOSE: To evaluate the fluoroquinolone susceptibilities of ocular isolate coagulase-negative staphylococci (CoNS), identified at the Microbiology Laboratory - UNIFESP. DESIGN: Experimental laboratory investigation. METHODS: The minimum inhibitory concentrations (MICs) of 21 strains of methicillin-resistant coagulase-negative staphylococci (MRCoNS) and 22 methicillin-sensitive coagulase-negative staphylococci (MSCoNS) to ciprofloxacin, ofloxacin, gatifloxacin and moxifloxacin were determined, using the E-test method standardized by the Clinical and Laboratory Standards Institute (CLSI/NCCLS). RESULTS: The MIC90s (µg/ml) for the second generation of tested fluoroquinolones were higher than the fourth generation, especially for the methicillin-resistant coagulase-negative staphylococci group. CONCLUSION: Our results indicate that methicillin-sensitive coagulase-negative staphylococci are more susceptible to quinolones than are methicillin-resistant coagulase-negative staphylococci and that fourth generation fluoroquinolones appear to be more potent, affecting even coagulase-negative staphylococcal strains resistant to second generation fluoroquinolones.

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