Use of amniotic membrane in trabeculectomy for the treatment of glaucoma: a pilot study

Arquivos Brasileiros de Oftalmologia

Ricardo Nunes Eliezer¹  Niro Kasahara¹  Cristiano Caixeta-umbelino¹  Renato Kingleufus Pinheiro¹  Carmo Mandia Junior¹  Roberto Freire Santiago Malta¹ 

[1] ,Santa Casa de Misericórdia de São Paulo Faculdade de Ciências Médicas Glaucoma ServiceSão Paulo SP ,Brazil

关键词: Glaucoma;    open-angle;    Trabeculectomy;    Intraocular pressure;    Biological dressings;    Postoperative complications;    Glaucoma de ângulo aberto;    Trabeculectomia;    Pressão intra-ocular;    Curativos biológicos;    Complicações pós-operatórias;   

DOI  :  10.1590/S0004-27492006000300005

来源: SciELO

【 摘 要 】

PURPOSE: To compare the safety and efficacy of human preserved amniotic membrane (AM) in the trabeculectomy for treatment of primary open-angle glaucoma. METHODS: A prospective, randomized clinical trial compared primary trabeculectomy with amniotic membrane (study group) and without amniotic membrane (control group) in the treatment of the glaucoma. Intraocular pressure (IOP), number of glaucoma medications and appearance of the bleb were compared between the two groups. Thirty-two patients divided into two groups of 16 patients were followed for a period of 12 months. RESULTS: The difference of the mean postoperative intraocular pressure between groups was not statistically significant (15.19 ± 3.33 in the control group and 12.81 ± 2.48 in the study group p=0.297) at one year follow-up. Postoperative number of medications decreased in both groups (p<0.001and p=0.007, study group and control respectively). At the end of a 12-month follow-up period, nine eyes (56.25%) showed thin, avascular blebs in the study group as compared to only one eye (6.25%) in the control group. CONCLUSIONS: Trabeculectomy with amniotic membrane and standard trabeculectomy promote lower postoperative intraocular pressure although results showed no statistically significant difference between groups regarding postoperative intraocular pressure after one year follow-up.

【 授权许可】

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