Late-onset persistent retinal microvascular changes after bone marrow transplantation: 3-year follow-up

Arquivos Brasileiros de Oftalmologia

Cristina Muccioli²  Rubens Belfort Jr²  Rodrigo Jorge¹  Michel Eid Farah²  Mauricio B. Pereira¹ 

[1] ,Universidade Federal de São Paulo Escola Paulista de Medicina Departamento de Oftalmologia

关键词: Bone marrow transplantation;    Adrenal cortex hormones;    Cyclosporins;    Retinal diseases;    Drug combinations;    Case report;    Follow-up;    Transplante de medula óssea;    Corticosteróides;    Ciclosporinas;    Doenças retinianas;    Combinação de medicamentos;    Relato de caso;    Seguimentos;   

DOI  :  10.1590/S0004-27492002000300017

来源: SciELO

【 摘 要 】

Purpose: To describe a case of persistent retinopathy after bone marrow transplantation in the absence of radiation therapy. Methods: Case Report. Results: A 42 year-old man developed bilateral visual loss 15 months after receiving a bone marrow transplant for acute leukemia. The patient was treated with a high dose of cyclosporin A and oral corticosteroids. No radiation therapy was given. Late-onset, multiple, bilateral cotton-wool spots developed 15 months after the bone marrow transplantation and still persist. After three years other cotton-wool spots arose in the absence of any immunosuppressive therapy. Conclusions: Bone marrow transplantation microvasculopathy of the retina may be related to certain combinations of chemotherapy drugs or immunosuppression itself and may persist in the absence of these immunosuppressive drugs.

【 授权许可】

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