Anais da Academia Brasileira de Ciências | |
Isolation, characterization and evaluation of antimicrobial and cytotoxic activity of estragole, obtained from the essential oil of croton zehntneri (euphorbiaceae) | |
Thallita C.b. Andrade1  Sidney G. De Lima1  Rivelilson M. Freitas1  MÁrcio S. Rocha1  Torequl Islam1  Teresinha G. Da Silva1  Gardenia C.g. MilitÃo1  | |
关键词: Antimicrobial; Croton zehntneri; cytotoxic; estragole; Antimicrobiana; Croton zehntneri; citotóxico; estragol; | |
DOI : 10.1590/0001-3765201520140111 | |
来源: SciELO | |
【 摘 要 】
Croton zehntneri (Euphorbiaceae) is a native aromatic plant from Northeast region of Brazil. The monoterpenoid estragole (ESL) has been isolated by classical chromatographic methods from the essential oil (EO) of C. zehnteneri leaves and characterized by GC-FID and GC-MS, its antimicrobial and cytotoxic potentials being assessed. The analysis of the EO enabled the identification of 100% of the integrated constituents, of which yield was about 1.8%. The main components identified were: eucalyptol, estragole (84.7%) and spathulenol. The dosage of 50 μg/disk of ESL presented fairly significant zones of inhibition against Gram-positive bacteria and fungi. The ESL presented toxicity against Artemia salina with LC50 and LC90 of 4,54 and 8,47 μg mL-1. However, in tumor inhibition assays (human cells), there were no rewarding inhibition in any of the human cancer cell lines (MCF-7, HEP-2 and NCI-H292).
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