In vitro anti-inflammatory effects of naturally-occurring compounds from two Lauraceae plants

Anais da Academia Brasileira de Ciências

Ericsson D. Coy-barrera¹  Luis E. Cuca-suarez¹ 

[1] ,Universidad Nacional de Colombia Facultad de Ciencias Departamento de QuímicaBogotá D.C,Colombia

关键词: COX;    furofuran lignans;    5-LOX;    Ocotea macrophylla;    platelet aggregation;    Pleurothyrium cinereum;    COX;    lignanos furofurânicos;    5-LOX;    Ocotea macrophylla;    agregação plaquetária;    Pleurothyrium cinereum;   

DOI  :  10.1590/S0001-37652011005000044

来源: SciELO

【 摘 要 】

The in vitro anti-inflammatory effects of seven known lignans and one dihydrochalcone isolated from the leaves of two Lauraceae species (Pleurothyrium cinereum and Ocotea macrophylla), were evaluated through the inhibition of COX-1, COX-2, 5-LOX and the aggregation of rabbit platelets induced by PAF, AA and ADP. (+)-de-4"-O--methylmagnolin 4 was found to be a potent COX-2/5-LOX dual inhibitor and PAF-antagonist (COX-2 IC50 2.27 µM; 5-LOX IC50 5.05 µM; PAF IC50 2.51 µM). However, all compounds exhibited an activity at different levels, indicating good anti-inflammatory properties to be considered in further structural optimization studies.

【 授权许可】

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