Anti-inflammatory effect of the ethanolic extract from Bowdichia virgilioides H.B.K stem bark

Anais da Academia Brasileira de Ciências

Wander M. Barros²  Vietla S.n. Rao¹  Regilane M. Silva²  Joaquim C.s. Lima¹  Domingos T.o. Martins² 

[1] ,Universidade Federal de Mato Grosso FCM Departamento de Ciências Básicas em SaúdeCuiabá MT ,Brasil

关键词: Bowdichia virgilioides;    Fabaceae;    stem bark extract;    anti-inflammatory activity;    Bowdichia virgilioides;    Fabaceae;    extrato da casca;    atividade anti-inflamatória;   

DOI  :  10.1590/S0001-37652010000300008

来源: SciELO

【 摘 要 】

Bowdichia virgilioides H.B.K stem bark (Fabaceae), locally known as "sucupira-preta", is a reputed folk-remedy to treat some inflammatory disorders. To validate its traditional claim, the ethanolic extract from B. virgilioides was evaluated in several animal models of inflammation and nociception. The extract at oral doses of 100 to 1000 mg/kg body weight caused a significant inhibition of carrageenan-induced hind paw oedema, suppression of exudate volume and leukocyte immigration in rat pleurisy induced by carrageenan, and reduction of granuloma weights in the model of subcutaneous granulomas promoted by cotton pellets. In addition, the plant extract significantly inhibited the vascular permeability increase induced by intraperitoneal acetic acid. It also showed marked antinociceptive effect in acetic acid-induced writhing test and in the second phase of formalin test in mice. These findings evidence the anti-inflammatory potential of Bowdichia virgilioides bark and supports its traditional use in inflammatory conditions.

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