Control of the skin scarring response

Anais da Academia Brasileira de Ciências

Lydia M. Ferreira¹  Alfredo Gragnani¹  Fabianne Furtado¹  Bernardo Hochman¹ 

[1] ,Universidade Federal de São Paulo Programa de Pós-Graduação em Cirurgia Plástica São Paulo SP ,Brasil

关键词: wound healing;    keratinocytes;    fibroblasts;    keloid;    tissue engineering;    skin;    plastic surgery;    cicatrização de feridas;    queratinócitos;    fibroblastos;    engenharia tissular;    pele;    cirurgia plástica;   

DOI  :  10.1590/S0001-37652009000300024

来源: SciELO

【 摘 要 】

There comes a time when the understanding of the cutaneous healing process becomes essential due to the need for a precocious tissue repair to reduce the physical, social, and psychological morbidity. Advances in the knowledge on the control of interaction among cells, matrix and growth factors will provide more information on the Regenerative Medicine, an emerging area of research in medical bioengineering. However, considering the dynamism and complexity of the cutaneous healing response, it is fundamental to understand the control mechanism exerted by the interaction and synergism of both systems, cutaneous nervous and central nervous, via hypothalamus hypophysis-adrenal axis, a relevant subject, but hardly ever explored. The present study reviews the neuro-immune-endocrine physiology of the skin responsible for its multiple functions and the extreme disturbances of the healing process, like the excess and deficiency of the extracellular matrix deposition.

【 授权许可】

CC BY   
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