Role of renin-angiotensin system in development of heart failure induced by myocardial infarction in rats

Anais da Academia Brasileira de Ciências

Daniel C. Trindade²  Raquel C. Trindade²  Michelle P. Marassi¹  Ornélia P.p.r. Martins²  Ricardo H. Costa-e-sousa²  Elisabete C. Mattos¹  Alcides Marinho-jr.²  Luís C. Reis¹  Emerson L. Olivares¹ 

[1] ,Universidade de Barra MansaBarra Mansa RJ ,Brasil

关键词: myocardial infarction;    electrocardiogram;    echocardiogram;    renin-angiotensin system;    captopril;    infarto do miocárdio;    eletrocardiograma;    ecocardiograma;    sistema renina-angiotensina;    captopril;   

DOI  :  10.1590/S0001-37652007000200008

来源: SciELO

【 摘 要 】

We investigated the morphologic and functional changes of infarcted rat hearts under a paradigm of angiotensinconverting enzyme inhibition. Myocardial infarction was induced by left coronary artery ligation and a control group (SHAM) underwent sham-operation. Infarcted rats received normal drinking water with (CAP group) or without (INF group) captopril. Functional assessment was performed by electro (ECG) and echocardiogram (ECHO) just before and 21 days after surgery. The ECG of INF and CAP showed similar values and resembled healed infarct after surgery. The most outstanding differences between INF and CAP were the prevention of the increase of P-wave and attenuation both in rightward deviation of the QRS axis and Q-wave amplitude in CAP compared with INF. The ECHO showed that captopril treatment improved the diastolic filling more than systolic performance. Cardiac dilatation and left congestive heart failure were observed only in INF. Both infarcted groups showed a scar tissue in the left ventricular wall, but the INF showed a higher scar area than CAP (49.7 ± 5.24 vs. 22.33 ± 6.19 respectively). These data suggest that the renin-angiotensin system induces morphologic and functional changes in post-infarcted rat hearts and which can be assessed by non-invasive exams.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License