The structural molecular biology network of the State of São Paulo, Brazil

Anais da Academia Brasileira de Ciências

João A.r.g. Barbosa²  Luis E.s. Netto¹  Chuck S. Farah¹  Sergio Schenkman¹  Rogério Meneghini¹ 

[1] ,Centro de Biologia Molecular Estrutural Laboratório Nacional de Luz Síncrotron Campinas SP ,Brasil

关键词: structural genomics;    protein crystallography;    nuclear magnetic resonance;    protein structure;    genômica estrutural;    cristalografia de proteínas;    ressonância nuclear magnética;    estrutura de proteínas;   

DOI  :  10.1590/S0001-37652006000200006

来源: SciELO

【 摘 要 】

This article describes the achievements of the Structural Molecular Biology Network (SMolBNet), a collaborative program of structural molecular biology, centered in the State of São Paulo, Brazil, and supported by São Paulo State Funding Agency (FAPESP). It gathers twenty scientific groups and is coordinated by the scientific staff of the Center of Structural Molecular Biology, at the National Laboratory of Synchrotron Light (LNLS), in Campinas. The SMolBNet program has been aimed at 1) solving the structure of proteins of interest related to the research projects of the groups. In some cases, the choice has been to select proteins of unknown function or of possible novel structure obtained from the sequenced genomes of the FAPESP genomic program; 2) providing the groups with training in all the steps of the protein structure determination: gene cloning, protein expression, protein purification, protein crystallization and structure determination. Having begun in 2001, the program has been successful in both aims. Here, four groups reveal their participation in the program and describe the structural aspects of the proteins they have selected to study.

【 授权许可】

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