期刊论文详细信息
Anais da Academia Brasileira de Ciências
The lizard cerebral cortex as a model to study neuronal regeneration
Carlos Lopez-garcia1  Asuncion Molowny1  Juan Nacher1  Xavier Ponsoda1  Francisco Sancho-bielsa1  Gregori Alonso-llosa1 
[1] ,Universidad de Valencia Lab. Neurobiologia Celular Burjasot Valencia ,Spain
关键词: medial cortex;    hippocampus;    postnatal neurogenesis;    neural stem cells;    zinc;    regeneration;    cortex medial;    hipocampo;    neurogênese pós-natal;    células-tronco;    zinco;    regeneração;   
DOI  :  10.1590/S0001-37652002000100006
来源: SciELO
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【 摘 要 】

The medial cerebral cortex of lizards, an area homologous to the hippocampal fascia dentata, shows delayed postnatal neurogenesis, i.e., cells in the medial cortex ependyma proliferate and give rise to immature neurons, which migrate to the cell layer. There, recruited neurons differentiate and give rise to zinc containing axons directed to the rest of cortical areas, thus resulting in a continuous growth of the medial cortex and its zinc-enriched axonal projection. This happens along the lizard life span, even in adult lizards, thus allowing one of their most important characteristics: neuronal regeneration. Experiments in our laboratory have shown that chemical lesion of the medial cortex (affecting up to 95% of its neurons) results in a cascade of events: first, massive neuronal death and axonal-dendritic retraction and, secondly, triggered ependymal-neuroblast proliferation and subsequent neo-histogenesis and regeneration of an almost new medial cortex, indistinguishable from a normal undamaged one. This is the only case to our knowledge of the regeneration of an amniote central nervous centre by new neuron production and neo-histogenesis. Thus the lizard cerebral cortex is a good model to study neuronal regeneration and the complex factors that regulate its neurogenetic, migratory and neo-synaptogenetic events.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License

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