Strategies by which some pathogenic trichomonads integrate diverse signals in the decision-making process

Anais da Academia Brasileira de Ciências

Luciene Bottentuit LÓpez²  Mariane Bandeira De Melo Braga²  Jaime Ortega LÓpez¹  Rossana Arroyo¹  Fernando Costa E Silva Filho² 

[1] ,Universidade Federal do Rio de Janeiro Instituto de Biofísica Carlos Chagas Filho Rio de Janeiro,Brazil

关键词: Trichomonas vaginalis;    Tritrichomonas foetus;    parasitic protozoa;    host-cell parasite interaction relationships;    trichomonal virulence;   

DOI  :  10.1590/S0001-37652000000200006

来源: SciELO

【 摘 要 】

The interaction between each one of Trichomonas vaginalis and Tritrichomonas foetus with their hosts is a complex process in which components associated to the cell surfaces of both parasites and host epithelial cells, and also to soluble components found in vaginal/urethral secretions, are involved. Either cytoadhesion or the cytotoxicity exerted by parasites to host cells can be dictated by virulence factors such as adhesins, cysteine proteinases, laminin-binding proteins, integrins, integrin-like molecules, a cell detachment factor, a pore-forming protein, and glycosidases among others. How trichomonads manipulate informations from the extracellular medium, transduce such informations, and respond to them by stimulating the activities of some surface molecules and/or releasing enzymes are the aspects concerning trichomonal virulence which are here briefly reviewed and discussed.

【 授权许可】

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