Mimics of copper proteins: structural and functional aspects

Anais da Academia Brasileira de Ciências

Ana Maria Da Costa Ferreira¹  Maria LÚcia Pires Dos Santos¹  Eleonice Maria Pereira¹  Marcos Oliveira Damasceno¹  Wendel Andrade Alves¹ 

[1] ,Universidade de São Paulo Instituto de Química Departamento de Química FundamentalSão Paulo SP ,Brasil

关键词: copper protein mimics;    copper diimine complexes;    EPR measurements;    characterization and reactivity studies;   

DOI  :  10.1590/S0001-37652000000100007

来源: SciELO

【 摘 要 】

The importance of copper as an essential element can be estimated by the wide range of copper proteins and enzymes playing different roles in biological systems. In the last decades many bioinorganic studies were developed on mimetic complexes of copper-dependent proteins, in order to verify the interrelations between structural and functional properties of active copper centers. Among the most studied copper ion ligand, diimine compounds have deserved special attention due their flexibility, facility of preparation, and ability to stabilize both oxidation states of this metal. In our laboratory, we have been investigating some Schiff base copper complexes as mimics of different proteins, with emphasis on functional aspects, trying to elucidate mechanisms of reaction, based on proposed intermediary species, in addition to molecular shapes. Particularly, mimics of the copper-zinc superoxide dismutase, and of monooxigenases and oxidases exhibiting dicopper sites are discussed in this work.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License