Candiduria in adults and children: prevalence and antifungal susceptibility in outpatient of Jataí-GO

Jornal Brasileiro de Patologia e Medicina Laboratorial

Izabela Alves De Sousa¹  Alexandre Braoios¹  Thaynara Gonzaga Santos¹  Juliano Alves De Lima¹  Rafael Menezes Da Costa¹ 

关键词: antifungal susceptibility test;    amphotericin B;    Candida;    candiduria;    fluconazole;    ketoconazole;    itraconazole;    antifungigrama;    anfotericina B;    Candida;    candidúria;    cetoconazol;    fluconazol;    itraconazol;   

DOI  :  10.5935/1676-2444.20140024

来源: SciELO

【 摘 要 】

Introduction: The term candiduria refers to the presence of yeast in urine and Candida albicans is the most common agent. In general, routine laboratories do not perform identification and cultivation of yeast. Objectives: To determine the prevalence of Candida species and to evaluate the antifungal susceptibility of the species isolated in urine of outpatients Jataí-GO, between January-October 2013. Material and method: Urine samples containing fungal structures were plated out on Sabouraud agar with chloramphenicol. Differentiation was taken with the urease test, nitrogen and carbon sources assimilation, germ tube test, morphology on cornmeal agar and chromogenic agar cultivation. Susceptibility was evaluated at antifungal itraconazole, fluconazole, amphotericin B and ketoconazole. Results: 1,215 urine tests were performed, and 64 had fungal structures (5.3%). Two samples were lost, thus here we considered 62 isolates. From this total, 43 were identified as C. albicans (67.2 %), eight C. glabrata (12.5 %), five C. krusei (7.8%), three C. tropicalis (4.7%), and three could not determine the species (4.7%). Amphotericin B and ketoconazole inhibited 94.9% of the isolates. On the other hand, 55.9% and 54.2 % were resistant to itraconazole and fluconazole, respectively. The resistance rates of both fluconazole and itraconazole for C. glabrata and C. albicans, as fluconazole for C. albicans and C. krusei, showed significant differences (p < 0.05). Conclusion: These data demonstrate the importance of conducting a full identification and susceptibility to antifungal agents in samples with yeast infection.

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