Solitary plexiform neurofibroma determining pyloric obstruction: a case report

Jornal Brasileiro de Patologia e Medicina Laboratorial

Eduardo Cambruzzi¹  Karla Lais Pêgas¹  Andreza Mariane De Azeredo¹  Isadora Bombassaro¹ 

关键词: neurofibroma;    pylorus;    gastric cancer;    gastrointestinal tract;    pathology;    neurofibroma;    piloro;    neoplasias gástricas;    trato gastrointestinal;    patologia;   

DOI  :  10.5935/1676-2444.20140022

来源: SciELO

【 摘 要 】

Solitary gastric plexiform neurofibroma (PN) is a very rare tumor that originates from the peripheral nerves. PN is a rare cause of pyloric obstruction. A 58 year-old man, reported epigastric discomfort, nausea, and vomiting for two months. Upper digestive endoscopy showed a moderate/accentuated pyloric stenosis. Computed tomography (CT) and echoendoscopy revealed a pyloric nodule. The patient underwent to distal gastrectomy. Macroscopically, a gray nodule measuring 1.1 × 1.0 × 1.0 cm was identified. Using microscopy, a benign tumor composed of enlarged tortuous nerve fascicles showing a neurofibromatous proliferation with mild atypia and myxoid matrix was found. The lesion showed positive immunoexpression for S100, Leu7, and epithelial membrane antigen (EMA), and was negative for CD117, DOG-1, desmin, and smooth muscle actin. The diagnosis of PN was then determined.

【 授权许可】

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