Study on sickle cell disease haplotypes reveals the African origin of Amapá's population

Jornal Brasileiro de Patologia e Medicina Laboratorial

Natália De Morais Castelo¹  Rafael Espíndola Do Nascimento¹  Artemis Socorro Do Nascimento Rodrigues¹ 

关键词: HbS haplotypes;    afro-descendants;    Amapá;    haplótipos HbS;    afrodescendentes;    Amapá;   

DOI  :  10.5935/1676-2444.20140006

来源: SciELO

【 摘 要 】

Introduction:Sickle cell disease (SCD) is a hereditary, hematologic, multifactorial disease, with high prevalence worldwide; its cause is a mutation in the sixth codon of the beta globin gene (βs).Objective:To identify the haplotypes present in people with SCD in Amapá, and relate them to African descent.Methods:We analyzed, by molecular techniques, 46 blood samples from people with SCD in Macapá, the capital of Amapá, with the purpose of obtaining information about haplotype frequency distribution, which helps understand the ethnic background of Amapá's population.Results:Our study revealed that the most frequent haplotype is Bantu (61.2%), followed by Benin (26.6%) and Senegal (12.2%). Results showed statistical differences from studies conducted in other regions. A high frequency of the Senegal haplotype stands out, in comparison with some Brazilian studies.Conclusion:Amapá's results exhibit unique characteristics when compared to haplotypes in other regions, with high frequency of Senegal and Benin haplotypes, absence of atypical, Cameroon and Saudi, confirming that Brazil shows ethnic background diversity, as well as different haplotype frequencies.

【 授权许可】

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