The differential diagnosis of inflammatory joint disease in maternal-fetal microchimerism

Jornal Brasileiro de Patologia e Medicina Laboratorial

Seme Youssef Reda²  Marina Lobato Martins¹ 

[1] ,Hemocentro regional de Grarapuava Production sector

关键词: hemotherapy service;    chimera;    pregnancies;    triage;    donor selection;    serviço de hemoterapia;    quimera;    gestações;    triagem;    seleção do doador;   

DOI  :  10.1590/S1676-24442013000600004

来源: SciELO

【 摘 要 】

This study aimed at making the differential diagnosis of joint disease in a case of genetic chimerism in a female multiparous donor from the Regional Blood Bank of Guarapuava-PR (Hemocentro Regional de Guarapuava-PR), who had had three pregnancies of male fetuses. The patient showed joint pain prior to the last donation. It was possible to identify fetal cells remaining in circulation 20 years after her last pregnancy. Laboratory tests for acute phase proteins revealed possible termination of immune tolerance to circulating fetal cells. Thus, a hypothesis of graft-versus-host disease was formulated to explain the joint disease manifested by the donor.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License