RAGE receptor and its soluble isoforms in diabetes mellitus complications

Jornal Brasileiro de Patologia e Medicina Laboratorial

Mauren Isfer Anghebem Oliveira²  Emanuel Maltempi De Souza¹  Fábio De Oliveira Pedrosa¹  Rosângela Roginski Réa¹  Alexessander Da Silva Couto Alves¹  Geraldo Picheth¹  Fabiane Gomes De Moraes Rego¹ 

[1] ,Pontifícia Universidade Católica do Paraná Escola de Saúde e Biocências

关键词: RAGE receptor;    RAGE soluble isoforms;    RAGE isoforms;    diabetes complications;    receptor RAGE;    isoformas solúveis de RAGE;    isoformas de RAGE;    complicações do diabetes;   

DOI  :  10.1590/S1676-24442013000200004

来源: SciELO

【 摘 要 】

Chronic hyperglycemia, which is present in all types of diabetes, increases the formation of advanced glycation end-products (AGEs). The interaction of AGEs with receptor of advanced glycation end-products (RAGE) initiates a cascade of pro-inflammatory and pro-coagulant processes that result in oxidative stress, stimulating the formation and accumulation of more AGE molecules. This cyclic process, denominated metabolic memory, may explain the persistency of diabetic vascular complications in patients with satisfactory glycemic control. The RAGE found in several cell membranes is also present in soluble isoforms (esRAGE and cRAGE), which are generated by alternative deoxyribonucleic acid splicing or by proteolytic cleavage. This review focuses on new research into these mediators as potential biomarkers for vascular complications in diabetes.

【 授权许可】

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