Primary osteosarcoma of the thyroid gland: report of a rare neoplasm

Jornal Brasileiro de Patologia e Medicina Laboratorial

Eduardo Cambruzzi²  João Grigoleti Scholl¹  Alberto Salgueiro Molinari¹  Karla Lais Pêgas¹ 

[1] ,Universidade Luterana do Brasil

关键词: osteosarcoma;    thyroid gland;    pathology;    immunohistochemistry;    osteossarcoma;    glândula tireoide;    patologia;    imuno-histoquímica;   

DOI  :  10.1590/S1676-24442013000100011

来源: SciELO

【 摘 要 】

Primary mesenchymal tumors of the thyroid gland are extremely rare. The authors report a case of primary thyroid osteosarcoma in a male patient presenting a tumoral mass in the neck. CT scan demonstrated a large tumor in the right thyroid lobe with areas of calcification. The surgical specimen consisted of a hard brown-gray tumor, measuring 13 × 11 × 7.5 cm. Microscopy revealed a high-grade malignant neoplasm composed of polygonal cells of intermediate size, chondroid pattern in some areas and osteoid formation. The process was immunonegative for AE1/AE3, glial fibrillary acidic protein (GFAP), epithelial membrane antigen (EMA), p53 and thyroid transcription factor-1 (TTF-1), and immunopositive for CD99 and S100. Thus the diagnosis of primary osteosarcoma of the thyroid gland was established.

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