Prognostic and predictive biomarkers for hypoxic regions on breast cancer: advances and challenges

Jornal Brasileiro de Patologia e Medicina Laboratorial

Moacyr Jesus Barreto De Melo Rêgo²  Eduardo Isidoro Carneiro Beltrão¹ 

[1] ,UFPE Research Center for Therapeutic Innovation NUPIT

关键词: hypoxia;    carbonic anhydrase IX;    hypoxia inducible factor;    breast cancer diagnostic;    hipóxia;    anidrase carbônica IX;    fator induzido por hipóxia;    diagnóstico de câncer de mama;   

DOI  :  10.1590/S1676-24442013000100010

来源: SciELO

【 摘 要 】

Hypoxia has been extensively studied in solid tumors mainly in breast cancers and it is commonly associated with chemotherapy and radiotherapy resistance. Hypoxia inducible factor (HIF)-1α is responsible for hypoxia in the tumor microenvironment and its molecular mechanisms as well as its therapeutic strategies have been described. However, a few investigations in the literature deal with its role in the hypoxic environment at diagnosis with the aim to guide therapeutic approaches. This study alerts researchers in pathology and oncology to the importance of assessing area extension as well as specific biomarkers, inasmuch as molecules reactive to hypoxia may indicate response to antiangiogenic therapy. The extension of hypoxic areas may alter the choice of therapeutic approach, insofar as some antiangiogenic treatments may considerably aggravate patient's clinical course since they create a hypoxic environment.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License