Immunohistochemistry contribution to the diagnosis of prostate cancer

Jornal Brasileiro de Patologia e Medicina Laboratorial

Míriam De Fátima Brasil Engelman²  Fiorita Gonzales Lopes Mundim¹  Rogério Mendes Grande¹  Lucas Ribeiro Borges De Carvalho¹  Felipe Moreira Ridolfi¹ 

[1] ,Universidade do Vale do Sapucaí Faculdade de Ciências da Saúde curso de Medicina

关键词: Prostate;    Immunohistochemistry;    Needle biopsy;    Adenocarcinoma;    Próstata;    Immuno-histoquímica;    Biópsia por agulha;    Adenocarcinoma;   

DOI  :  10.1590/S1676-24442012000400008

来源: SciELO

【 摘 要 】

INTRODUCTION: Efforts for the identification of prostate cancer in the initial clinical and pathological stages led to an increase in the number of biopsies, sometimes making the histological diagnosis of adenocarcinoma difficult. This is due to the presence of minimal carcinoma or atypical glands suspicious for carcinoma, also known as atypical small acinar proliferation (ASAP). In these cases, the use of immunohistochemistry (IHC) has become a common practice in laboratories of pathology. OBJECTIVES: The aims of this study were to assess the incidence of diagnoses of ASAP and minimal adenocarcinoma in two laboratories of pathology and to evaluate the contribution of IHC and repeat biopsy to the diagnosis of prostate cancer. METHODS: We reviewed 641 sets of modified sextant needle biopsies of the prostate performed in two laboratories of pathology between January 2005 and December 2010. IHC using 34βE12 and p63 antibodies was performed on 35 of 73 (11.38%) cases diagnosed as ASAP and on 7 (1.1%) cases diagnosed as minimal adenocarcinoma. RESULTS: The incidence of ASAP diagnosis was 11.38% (n = 73). IHC was performed in 35 of the 73 ASAP cases and provided conclusive results in 31 cases (88.57%), resulting in a final diagnosis of adenocarcinoma in 19 patients (54.28%), benign lesions in 12 patients (34 28%); only 4 (11.42%) were inconclusive. CONCLUSION: The results suggest that IHC should be routinely used in evaluation of borderline biopsies and in ASAP cases. IHC strongly contributes to the diagnosis of prostate cancer.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License