Assessment of mutagenicity and cytotoxicity of Solanum paniculatum L. extracts using in vivo micronucleus test in mice

Brazilian Journal of Biology

Pm. Vieira²  Sc. Santos¹  L. Chen-chen² 

[1] ,Universidade Federal de Goiás Instituto de Ciências Biológicas Departamento de Biologia GeralGoiânia GO ,Brazil

关键词: mutagenicity;    cytotoxicity;    Solanum paniculatum L.;    micronucleus;    mice;    mutagenicidade;    citotoxicidade;    Solanum paniculatum L.;    micronúcleo;    camundongos;   

DOI  :  10.1590/S1519-69842010000300017

来源: SciELO

【 摘 要 】

Solanum paniculatum L. is a plant species widespread throughout tropical America, especially in the Brazilian Savanna region. It is used in Brazil for culinary purposes and in folk medicine to treat liver and gastric dysfunctions, as well as hangovers. Because of the wide use of this plant as a therapeutic resource and food, the present study aimed at evaluating the mutagenic and cytotoxic effects of S. paniculatum ethanolic leaf and fruit extracts using the mouse bone marrow micronucleus test. Our results indicate that neither S. paniculatum ethanolic leaf extract nor its ethanolic fruit extract exhibited mutagenic effect in mice bone marrow; however, at higher doses, both extracts presented cytotoxic activity.

【 授权许可】

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