Poor glycemic control impacts linear and non-linear dynamics of heart rate in DM type 2

Revista Brasileira de Medicina do Esporte

Daniela Bassi¹  Vivian Maria Arakelian¹  Renata Gonçalves Mendes¹  Flávia Cristina Rossi Caruso¹  José Carlos Bonjorno Júnior¹  Katiany Thays Lopes Zangrando¹  Cláudio Ricardo De Oliveira¹  Jacob Haus¹  Ross Arena¹  Audrey Borghi-silva¹ 

关键词: diabetes mellitus;    type 2;    blood glucose;    heart rate;    autonomic nervous system;    hemoglobin A;    glycosylated;    diabetes mellitus tipo 2;    glicemia;    frequência cardíaca;    sistema nervoso autônomo;    hemoglobina A glicosilada;    diabetes mellitus tipo 2;    glucemia;    frecuencia cardíaca;    sistema nervioso autónomo;    hemoglobina A glucosilada;   

DOI  :  10.1590/1517-869220152104150003

来源: SciELO

【 摘 要 】

INTRODUCTION: It is well known that type 2 diabetes mellitus (T2DM) produces cardiovascular autonomic neuropathy (CAN), which may affect the cardiac autonomic modulation. However, it is unclear whether the lack of glycemic control in T2DM without CAN could impact negatively on cardiac autonomic modulation. Objective: To evaluate the relationship between glycemic control and cardiac autonomic modulation in individuals with T2DM without CAN. Descriptive, prospective and cross sectional study. METHODS: Forty-nine patients with T2DM (51±7 years) were divided into two groups according to glycosylated hemoglobin (HbA1c): G1≤7% and G2>7.0%. Resting heart rate (HR) and RR interval (RRi) were obtained and calculated by linear (Mean iRR; Mean HR; rMSSD; STD RR; LF; HF; LF/HF, TINN and RR Tri,) and non-linear (SD1; SD2; DFα1; DFα2, Shannon entropy; ApEn; SampEn and CD) methods of heart rate variability (HRV). Insulin, HOMA-IR, fasting glucose and HbA1c were obtained by blood tests. RESULTS: G2 (HbA1c≤7%) showed lower values for the mean of iRR; STD RR; RR Tri, TINN, SD2, CD and higher mean HR when compared with G1 (HbA1c > 7%). Additionally, HbA1c correlated negatively with mean RRi (r=0.28, p=0.044); STD RR (r=0.33, p=0.017); RR Tri (r=-0.35, p=0.013), SD2 (r=-0.39, p=0.004) and positively with mean HR (r=0.28, p=0.045). Finally, fasting glucose correlated negatively with STD RR (r=-0.36, p=0.010); RR Tri (r=-0.36, p=0.010); TINN (r=-0.33, p=0.019) and SD2 (r=-0.42, p=0.002). CONCLUSION: We concluded that poor glycemic control is related to cardiac autonomic modulation indices in individuals with T2DM even if they do not present cardiovascular autonomic neuropathy.

【 授权许可】

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