Dormancy models for Mycobacterium tuberculosis: A minireview

Brazilian Journal of Microbiology

Amani M. Alnimr¹ 

关键词: dormancy;    latency;    tuberculosis;    stationary-phase;   

DOI  :  10.1590/S1517-838246320140507

来源: SciELO

【 摘 要 】

Dormancy models for Mycobacterium tuberculosis play important roles in understanding various aspects of tuberculosis pathogenesis and in the testing of novel therapeutic regimens. By simulating the latent tuberculosis infection, in which the bacteria exist in a non-replicative state, the models demonstrate reduced susceptibility to antimycobacterial agents. This minireview outlines the models available for simulating latent tuberculosis both in vitro and in several animal species. Additionally, this minireview discusses the advantages and disadvantages of these models for investigating the bacterial subpopulations and susceptibilities to sterilization by various antituberculosis drugs.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License