Production of actinomycin-D by the mutant of a new isolate of Streptomyces sindenensis

Brazilian Journal of Microbiology

Vandana Praveen²  C.k.m. Tripathi²  Vinod Bihari²  S.c. Srivastava¹ 

[1] ,Central Drug Research Institute Fermentation Technology Division ,India

关键词: actinomycin-D;    antibiotics;    Streptomyces;    mutation;    actinomicina-D;    antibióticos;    Streptomyces;    mutação;   

DOI  :  10.1590/S1517-83822008000400017

来源: SciELO

【 摘 要 】

An actinomycin-D producing strain was isolated from soil and characterized as Streptomyces sindenensis. The culture was subjected to UV irradiation and a mutant with 400% higher actinomycin-D production was isolated (400 mg/l-1 as compared to 80 mg/l-1 produced by the parent). Production medium was optimized and antibiotic yield with the mutant was enhanced to 850 mg/l-1 which is 963% higher as compared with the parent.

【 授权许可】

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