Carbon catabolite repression of retamycin production by Streptomyces olindensis ICB20

Brazilian Journal of Microbiology

Olavo Ossamu Inoue²  Willibaldo Schmidell Netto¹  Gabriel Padilla¹  Maria Cândida Reginato Facciotti² 

[1] ,Universidade de São Paulo Escola Politécnica Departamento de Engenharia Química SP ,Brasil

关键词: Streptomyces;    anthracyclines;    carbon catabolite repression;    Streptomyces;    antraciclinas;    repressão catabólica;   

DOI  :  10.1590/S1517-83822007000100012

来源: SciELO

【 摘 要 】

Retamycin is an anthracyclinic antitumoral complex produced by Streptomyces olindensis ICB20. In this work the influence of different glucose concentrations in the feed medium on the production of retamycin was studied. Chemostat cultures employing glucose concentration varying between 10 g/L and 25 g/L showed that use of high glucose concentration resulted in catabolite repression of the biosynthesis of the antitumoral. The highest specific retamycin production rate, qRTM = 7.8 mg/g.h, was obtained when glucose concentration was 10 g/L. The lowest value of qRTM, 2.5 mg/g.h, was observed when glucose concentration was 20 and 25 g/L. The residual glucose concentration varied from 0 to 13 g/L, as the glucose concentration in the feed was increased from 10 to 25 g/L.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License