In vitro activity of antifungal and antiseptic agents against dermatophyte isolates from patients with tinea pedis

Brazilian Journal of Microbiology

Maria Magali Stelato Rocha Soares²  Arlete Emily Cury¹ 

[1] ,Pontifícia Universidade Católica de Campinas Faculdade de Ciências Farmacêuticas Instituto de Ciências Biológicas e QuímicasCampinas SP ,Brasil

关键词: dermatophytes;    antifungal agents;    antiseptic agents;    susceptibility testing;    tinea pedis;    dermatófitos;    antifúngicos;    anti-sépticos;    teste de susceptibilidade;    tinea pedis;   

DOI  :  10.1590/S1517-83822001000200012

来源: SciELO

【 摘 要 】

The in vitro activity of antifungal and antiseptic agents were evaluated against dermatophytes isolated from patients with tinea pedis. The antifungals studied were: ciclopirox olamine, cetoconazole, tolciclate and terbinafine, and the antiseptics were: povidine iodine (PVPI), propolis, Fungol®, Andriodermol®, and boric acid. The minimum inhibitory concentration (MIC) or the minimal dilution concentration (MDC) was determined by an agar dilution method using modified yeast nitrogen agar base, and the minimum fungicidal concentration (MFC) or minimum fungicidal dilution (MFD) was determined with subcultures on Sabouraud dextrose agar. All drugs studied were active against the dermatophytes at lower concentrations than those used in products and/or pharmaceutical preparations for topical use. Some antifungal agents, mainly terbinafine and tolciclate, presented higher efficacy than the other drugs, with lower MICs and MFCs values. It was concluded that the use of these antiseptic drugs represent an excellent alternative for the topical treatment of tinea pedis. For the treatment of severe cases these are the antifungal agents of choice.

【 授权许可】

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