Hepatoprotective effects of Iranian Hypericum scabrum essential oils against oxidative stress induced by acetaminophen in rats

Brazilian Archives of Biology and Technology

Abolfazl Dadkhah²  Faezeh Fatemi¹  Mohsen Eslami Farsani¹  Kambiz Roshanaei¹  Mahdi Alipour¹  Hadi Aligolzadeh¹ 

[1] ,Islamic Azad University Faculty of Medicine Department of MedicineQom I.R ,Iran

关键词: Hypericum scabrum;    essential oils;    Acetaminophen;    Rat;    Oxidative stress;    Liver;   

DOI  :  10.1590/S1516-89132014005000012

来源: SciELO

【 摘 要 】

This studied examined the protective role of Hypericum scabrum oils (100 and 200 mg/kg b.w, i.p) on acetaminophen-induced liver damages in the rat. The hepatic oxidative/antioxidant parameters such as lipid peroxidation (LP), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and ferric reducing ability of plasma (FRAP) were measured 2, 4, 8, 16 and 24h after the treatments confirmed by histopathological consideration. The results indicated that increased levels of hepatic LP and FRAP and SOD activity were reversed in the rats treated with oils. In addition, the depleted GSH were compensated with the oil treatments. The protective effect of the oils was further confirmed by the histophatological examination carried out on liver biopsies. The data pointed out that H. scabrum oil could modulate the hepatic toxicity induced by the APAP through adjusting the oxidative stress/antioxidant parameters and could be of potential candidate for the treatment of acetaminophen induced oxidative stress liver damages.

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