TT virus in peripheral blood cells from patients with human papillomavirus (HPV): investigating association with cervical carcinoma

Brazilian Archives of Biology and Technology

Patrícia Sayuri Suzuki²  Karen Brajão De Oliveira²  Ana Cristina Do Amaral Herrera¹  Sueli Donizete Borelli¹  Roberta Losi Guembarovski²  Carlos Eduardo Coral De Oliveira²  Julie Massayo Maeda Oda²  Patricia Midori Murobushi Ozawa²  Maria Angelica Ehara Watanabe² 

[1] ,Universidade Estadual de Londrina Centro de Ciências Biológicas Departamento de Ciências PatológicasLondrina PR ,Brasil

关键词: TTV DNA;    HPV;    cervical cancer;   

DOI  :  10.1590/S1516-89132013005000017

来源: SciELO

【 摘 要 】

Torque Teno Virus (TTV) presence was investigated in peripheral blood of 117 brazilian women by nested polymerase chain reaction. TTV DNA was observed in 18.6% of healthy donors and in 24.32% Human Papillomavirus (HPV) patients. TTV presence was also investigated in the HPV positive group for comparison between the cervical cancer and noncancerous patients. TTV DNA prevalence was significantly higher among the HPV positive patients with cervical cancer (57.14%) than in HPV noncancerous patients (16.67%). Thus, the presence of TTV infection could be a risk factor for cancer development in the patients presenting HPV-TTV coinfection. Further studies are required to clarify the TTV influence in HPV pathogenesis.

【 授权许可】

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