Colon cancer and swimming exercise: effect on wistar rat testes

Brazilian Archives of Biology and Technology

Karine Moura De Freitas²  Antônio José Natali¹  Wellington Lunz¹  Kyvia Lugate Cardoso Costa¹  Rodrigo Paula Leite²  Heidi Dolder²  Sérgio Luis Pinto Da Matta¹ 

[1] ,Universidade Estadual de Campinas Instituto de Biologia Departamento de Biologia Estrutural e FuncionalCampinas SP ,Brasil

关键词: 1;    2-dimethylhydrazine;    fertility;    reproduction;    spermatogenesis;   

DOI  :  10.1590/S1516-89132013000400005

来源: SciELO

【 摘 要 】

This study was undertaken to determine whether colon cancer (CC) and chronic swimming exercise alter rat testis. Eleven weeks old rats were distributed into control group (n=6) and the groups that were induced to develop CC by dimethylhydrazine injections (nEG, EG0, EG2 and EG4; n=10 each group). In the group nEG, the rats did not swim, whereas groups EG0, EG2 and EG4, underwent a swimming program with distinct loads (0, 2 and 4% of body mass, respectively) for 35 weeks. The morphometry, stereology and cell counts showed damage caused by the CC on the germ epithelium. These results were noteworthy since this was the first report to associate the CC with testicular damage. Swimming exercise had no significant role in reducing, or increasing the CC effects on the testis, despite having slightly improved the testis structure of the exercised rats without load. In conclusion, CC caused testis impairment, which could not be avoided by the swimming exercise.

【 授权许可】

CC BY-NC   
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