Mimosine and cyclophosphamide: a potential new combination therapy used to prevent tumor development

Brazilian Archives of Biology and Technology

Vânius Vinícius Dipe²  André Tadeu Gotardo²  Mitsue Haraguchi¹  Silvana Lima Górniak² 

[1] ,Universidade de São Paulo Faculdade de Medicina Veterinária e Zootecnia Centro de Pesquisa de Toxicologia VeterináriaSão Paulo SP ,Brasil

关键词: Leucaena leucocephala;    Mimosine;    Ehrlich tumor;    Cyclophosphamide;    Anticancer activity;   

DOI  :  10.1590/S1516-89132012000600010

来源: SciELO

【 摘 要 】

The effects of mimosine (MI), which is an amino acid that is derived from Leucaena leucocephala, were evaluated on the growth of ascitic Ehrlich tumors, and the effects of the combination treatment of MI and cyclophosphamide (CY) on tumor growth were also assessed. Mice were divided into groups that received the following treatments over the course of 20 days: phosphate buffer solution (CO), MI, Ehrlich cells (E), E plus CY (EC), E plus MI (EM) and E plus MI and CY (EMC). No signs of toxicity were detected in the mice from the MI group. The mice from the EMC group showed reductions in body weights when compared with those from the E group. The animals from the EC, EM and EMC groups showed reductions in ascitic volume compared with those from the E group. The mice from the EMC group showed reductions in total cell numbers of ascitic fluid compared with those from the E, EC and EM groups. The combination of MI and CY was the most effective treatment for Ehrlich tumor ascites.

【 授权许可】

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