Neonatally induced diabetes: liver glycogen storage in pregnant rats

Brazilian Archives of Biology and Technology

Isabela Lovizutto Iessi²  Aline Bueno²  Yuri Karen Sinzato²  Ana Paula Machado Spada²  Marilza Vieira Cunha Rudge²  Maricê Thereza Correa Domingues Heubel¹  Débora Cristina Damasceno² 

[1],Universidade Estadual Paulista Departamento de Ginecologia e Obstetrícia Laboratório de Pesquisa Experimental de Ginecologia e ObstetríciaBotucatu SP ,Brasil

关键词: pregnancy;    rat;    hyperglycemia;    glycogen storage liver;    mild diabetes;    hyperglycemia;   

DOI  :  10.1590/S1516-89132012000200010

来源: SciELO

【 摘 要 】

The aim of this sstudy was to evaluate the liver glycogen storage in pregnant rats presenting neonatal streptozotocin-induced diabetes and to establish a relation with glycemia and insulin levels. Wistar rats were divided in to two groups: 1) Mild Diabetes (STZ) - received streptozotocin (glycemia from 120 to 300 mg/dL), 2) Control - received vehicle (glycemia below 120 mg/dL). At days 0, 7, 14 and 21 of the pregnancy, body weight and glycemia were evaluated. At day 21 of the pregnancy, the rats were anesthetized for blood and liver collection so as to determine insulin and liver glycogen, which showed no changes in the STZ group as compared to the controls. In the STZ group, maternal weight gain were lower as compared to those in the control group. Significantly increased glycemia was observed at days 0 and 14 of the pregnancy in the STZ group. Therefore, neonatally induced diabetes in the rats did not cause metabolic changes that impaired insulin and liver glycogen relation in these rats.

【 授权许可】

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