Antidiabetic activities of ethanol extract of dry matters of culture broth of Coriolus versiolor in submerged culture

Brazilian Archives of Biology and Technology

Zuofa Zhang²  Guoying Lv²  Huijuan Pan²  Leandro Freire Dos Santos¹  Menghai Fan¹  Carlos Ricardo Soccol¹  Vanete Thomaz-soccol¹  Luiz Gustavo Lacerda¹  Marco Aurélio Da Silva Carvalho Filho¹  Leifa Fan² 

[1] ,Institute of Horticulture Zhejiang Academy of Agricultural Sciences ,China

关键词: Coriolus versiolor;    Antihyperglycemic;    Antilipidperoxidative;    Diabetes;   

DOI  :  10.1590/S1516-89132011000400008

来源: SciELO

【 摘 要 】

The study aimed to investigate the antihyperglycemic and antilipidperoxidative effects of ethanol extract of the dry matter from culture broth of Coriolus versicolor (ECBC) in streptozotocin-induced diabetes mice. Blood glucose level, insulin level, total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol(LDL-C), high density lipoprotein -cholesterol (HDL-C) in serum and reduced glutathione level (GSH), lipid peroxidation, glycogen, antioxidant enzymes in liver were evaluated. Moreover, histopathological observation was conducted. Streptozotocin treatment (150 mg/kg body weight) induced the decrease of GSH level, antioxidant enzymes activities, glycogen content in liver, HDL-C content and insulin level in serum, accompanied by the elevation of the lipid peroxidation in liver, serum blood glucose level, contents of TC, TG and LDL-C. Treatment with ECBC restored the changes in the above parameters up to the basal level. The protective effects were further supported by the attenuation of the degree of pancreas damage in ECBC treated mice.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License