Modeling for Taxol® Separation in a simulated moving bed

Brazilian Archives of Biology and Technology

Marco Aurelio Cremasco¹  Axel Nicolas Starqui¹ 

[1] ,Universidade Estadual de Campinas Faculdade de Engenharia Química Campinas SP ,Brasil

关键词: Cancer;    Taxol;    Simulated moving bed;    Computer simulation;    Multicomponent separation;   

DOI  :  10.1590/S1516-89132010000600020

来源: SciELO

【 摘 要 】

This work presents an alternative numerical resolution strategy for a model to describe the dynamic of linear adsorption processes involving multicomponent mixture of taxanes with Taxol® (paclitaxel), a powerful anti-cancer agent, and non-identified impurities, in a Simulated Moving Bed (SMB) system. To solve the model, a hybrid method were used. The liquid concentration inside the particles was found analytically and was related with the liquid bed concentration using Duhamel's theorem. The results from simulation were compared with experimental ones from the literature, showing a good agreement, which demonstrated the applicability of the model and of the hybrid resolution proposed.

【 授权许可】

CC BY-NC   
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