Thermodynamics of molecular recognitions between antineoplastic drug taxol and phosphatidylcholine

Brazilian Archives of Biology and Technology

Erhan Süleymanoglu¹ 

[1] ,Gazi University Faculty of Pharmacy Department of Pharmaceutical ChemistryAnkara,Turkey

关键词: Antineoplastic agents;    chemotherapy;    Taxol;    phoshatidylcholine;    Taxol-membrane interactions;    membrane fluidity;   

DOI  :  10.1590/S1516-89132010000600011

来源: SciELO

【 摘 要 】

The aim of this study was to study the basic features of Taxol recognition with phospholipids by applying the thermodynamic and spectroscopic measurements. The obtained information could be used further for deductions on its precise cellular and pharmacological mechanisms of action, on improvements of its solubility properties by phospholipids, as well as for designing the novel lipidic carriers for drug delivery.

【 授权许可】

CC BY-NC   
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