Effect of oligofructose-enriched inulin on bone metabolism in girls with low calcium intakes

Brazilian Archives of Biology and Technology

Maria Cristina Corrêa De Souza²  Franco Maria Lajolo²  Ligia De Araujo Martini¹  Nelton Bespalez Correa¹  Milana Cara Dan²  Elizabete Wenzel De Menezes² 

[1] ,Universidade de São Paulo Faculdade de Ciências Farmacêuticas Laboratório de Química; Bioquímica e Biologia Molecular de AlimentosSão Paulo SP ,Brasil

关键词: Oligofructose-enriched inulin;    calcium intakes;    bone markers;    prepubertal girls;    prebiotics;    bone and mineral metabolism;   

DOI  :  10.1590/S1516-89132010000100024

来源: SciELO

【 摘 要 】

In the present clinical study, the effect of oligofructose-enriched inulin was studied on bone metabolism in girls from 9 to 12 years old, with low habitual calcium intakes, who attended public schools. Two calcium-enriched formulations, supplemented with oligofructose-enriched inulin (test drink) or without (standard drink) were made. Sixty pre-pubertal girls were randomized into a double-blind and crossover design, divided into three groups and received one daily portion of either the standard drink (group 1) or test drink (group 2) during 11 weeks, followed by a three-week washout period. Group control did not receive any supplementation. Biochemical evaluations of serum calcium, intact parathyroid hormone - iPTH - and bone alkaline phosphatase - BAP - were performed at baseline and after 4, 8 and 11 weeks of each intervention period. In group 1, a significant increase in serum calcium and BAP and a reduction of iPTH were observed after consumption of the test drink.

【 授权许可】

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