Analgesic and anti-inflammatory properties of essential oil from Ageratum fastigiatum

Brazilian Archives of Biology and Technology

Glauciemar Del-vechio-vieira²  Orlando Vieira De Sousa¹  Mariza Abreu Miranda¹  Luci Senna-valle²  Maria Auxiliadora Coelho Kaplan² 

[1] ,Museu Nacional Departamento de Botânica

关键词: Ageratum fastigiatum;    Essential oil;    Nociception;    Inflammation;   

DOI  :  10.1590/S1516-89132009000500008

来源: SciELO

【 摘 要 】

The chemical composition, analgesic and anti-inflammatory properties of essential oil from Ageratum fastigiatum were investigated. The main compounds found in the essential oil were germacrene D, α-humulene and β-cedrene. The oil, with LD50 of 2.50 g/kg, inhibited the acetic acid-induced writhing at the dose of 200 mg/kg. In the formalin test, the oil inhibited the first phase (200 mg/kg) and the second phase (100 mg/kg and 200 mg/kg). In the hot plate test, after 30 and 60 min of treatment the doses of 100 and 200 mg/kg increased the reaction time. The antiedematogenic effect, reduction on the exudate volume and leukocyte mobilization were observed at the doses of 100 and 200 mg/kg. The results indicated that A. fastigiatum possessed the analgesic and anti-inflammatory properties that supported the popular medicinal use of the plant.

【 授权许可】

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