Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomy

Brazilian Archives of Biology and Technology

Kércia Regina Santos Gomes Pereira²  Maria Kadja Meneses Torres Açucena²  Arthur Villarim Neto²  Amália Cínthia Meneses Rêgo²  Mário Bernardo-filho¹  Ítalo Medeiros Azevedo¹  Irami Araújo Filho¹  Aldo Cunha Medeiros¹ 

[1] ,Universidade Federal do Rio Grande do Norte Centro de Ciências da Saúde RN,Brasil

关键词: splenectomy;    sodium phytate;    biodistribution;    liver;    esplenectomia;    fitato de sódio;    biodistribuição;    fígado;   

DOI  :  10.1590/S1516-89132008000700033

来源: SciELO

【 摘 要 】

Drugs and surgery can interfere with the biodistribution of radiopharmaceuticals and data about the effect of splenectomy on the metabolism of phytate-Tc-99m are scarce. This study aimed at evaluating the interference of splenectomy on phytate-Tc-99m biodistribution and liver function in rats. The SP group rats (n=6) underwent splenectomy. In group C (control) the animals were not operated on. After 15 days, all rats were injected with 0.1mL of Tc-99m-phytate via orbital plexus (0.66MBq). After 30 minutes, liver samples were harvested, weighed and the percentage of radioactivity per gram (%ATI/g) was determined by a Wizard Perkin-Elme gama counter. The ATI%/g in splenectomized rats (0.99±0.02) was significantly higher than in controls (0.4±0.02), (p=0.034). ALT, AST and HDL were significantly lower in SP rats (p= 0.001) and leukocytosis was observed in SP rats. In conclusion, splenectomy in rats changed the hepatic biodistribution of Tc-99m-phytate and liver enzimatic activity.

【 授权许可】

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